Selected Publications

  1. Using a Liquid Biopsy, Circulating Tumor Cell Based Approach for Determination of HER2 Amplification Status in Patient Samples.
    Xiaojie, Zhang, Janet C. Dickerson, Stephenie Jones, Judy Muller-Cohn, Ph.D., Yipeng Wang, Ph.D., Rolf Muller Ph.D., and Kay Yeung. M.D., Ph.D.;  42nd Annual Miami Breast Cancer Conference, March 7-10, 2024

  2. Circulating Tumor Cell Subpopulations Predict Treatment Outcome in Pancreatic Ductal Adenocarcinoma (PDAC) Patients.
    Ian M. Freed, Anup Kasi, Oluwadamilola Fateru, Mengjia Hu, Phasin Gonzalez, Nyla Weatherington, Harsh Pathak, Stephen Hyter, Weijing Sun, Raed Al-Rajabi, Joaquina Baranda, Mateusz L. Hubert, Prabhakar Chalise, Andrew K. Godwin, Malgorzata A. Witek, Steven Soper. Cells 2023, 12, 2266
  3. Assessing Breast Cancer Molecular Subtypes Using Extracellular Vesicles’ mRNA.
    Mengjia Hu, Virginia Brown, Joshua M Jackson, Harshani Wijerathne, Harsh Pathak, Devin C Koestler, Emily Nissen, Mateusz L Hupert, Rolf Muller, Andrew K Godwin, Malgorzata A Witek, Steven A Soper. Anal Chem. 2023. PMID: 37071799
  4. Microfluidic affinity selection of active SARS-CoV-2 virus particles.
    Sachindra S.T. Gamage, Thilanga N. Pahattuge, Harshani Wijerathne, Katie Childers, Swarnagowri Vaidyanathan, Uditha S. Athapattu, Lulu Zhang, Zheng Zhao, Mateusz L. Hupert, Rolf M. Muller, Judy Muller-Cohn, Janet Dickerson, Dylan Dufek, Brian V. Geisbrecht, Harsh Pathak, Ziyan Pessetto, Gregory N. Gan, Junseo Choi, Sunggook Park, Andrew K. Godwin, Malgorzata A. Witek, Steven A. Soper. Science Advances, Vol 8, No. 39
  5. Affinity enrichment of extracellular vesicles from plasma reveals mRNA changes associated with acute ischemic stroke. Harshani Wijerathne, Malgorzata A. Witek, Joshua M. Jackson, Virginia Brown, Mateusz L. Hupert, Kristina Herrera, Cameron Kramer, Abigail E. Davidow, Yan Li, Alison E. Baird, Michael C. Murphy & Steven A. Soper. Biology volume 3, Article number: 613 (2020)
  6. Identification of fetal aneuploidy with dual-probe fluorescence in situ hybridization analysis in circulating trophoblasts after enrichment using a high-sensitivity microfluidic platform Jiri Sonek, Rolf Muller, Judy Muller-Cohn, Janet Dickerson, Brenda Garcia Lopez, Kulvinder Kaur, Jennifer Barber-Singh, Dylan Dufek, Adam Kinney Hiett, Philip Buchanan. Prenatal Diagnostics 2021, 41(13) 1701-1708
  7. Detection of 69,XXX karyotype in circulating trophoblasts using fluorescence in-situ hybridization after enrichment using novel high-throughput microfluidic platform. Sonek J, Muller R, Pfau R, Buchanan P. Ultrasound Obstet Gynecol. 2021 Apr;57(4):650-651. doi: 10.1002/uog.23586. Epub 2021 Mar 12. PMID: 33428295
  8. Visible photorelease of liquid biopsy markers following microfluidic affinity-enrichment, Pahattuge TN , Jackson JM , Digamber R , Wijerathne H , Brown V , Witek MA , Perera C , Givens RS , Peterson BR , Soper SA. Chem Commun (Camb). 2020 Apr 14;56(29):4098-4101
  9. Isolation of circulating plasma cells from blood of patients diagnosed with clonal plasma cell disorders using cell selection microfluidics. Kamande JW, Lindell MAM, Witek MA, Voorhees PM, Soper SA. Integr Biol (Camb). 2018 Feb 19;10(2):82-91. doi: 10.1039/c7ib00183e. PMID: 29372735; PMCID: PMC5877822
  10. Discrete microfluidics for the isolation of circulating tumor cell subpopulations targeting fibroblast activation protein alpha and epithelial cell adhesion molecule. Witek MA, Aufforth RD, Wang H, Kamande JW, Jackson JM, Pullagurla SR, Hupert ML, Usary J, Wysham WZ, Hilliard D, Montgomery S, Bae-Jump V, Carey LA, Gehrig PA, Milowsky MI, Perou CM, Soper JT, Whang YE, Yeh JJ, Martin G, Soper SA. NPJ Precis Oncol. 2017;1:24. doi: 10.1038/s41698-017-0028-8. Epub 2017 Jul 25. PMID: 29657983; PMCID: PMC5871807
  11. Thermoplastic nanofluidic devices for biomedical applications. Weerakoon-Ratnayake KM, O’Neil CE, Uba FI, Soper SA. Lab Chip. 2017 Jan 31;17(3):362-381. doi: 10.1039/c6lc01173j. PMID: 28009883; PMCID: PMC5285477
  12. Materials and microfluidics: enabling the efficient isolation and analysis of circulating tumour cells. Jackson JM, Witek MA, Kamande JW, Soper SA. Chem Soc Rev. 2017 Jul 17;46(14):4245-4280. doi: 10.1039/c7cs00016b. PMID: 28632258; PMCID: PMC5576189
  13. Microfluidics for the detection of minimal residual disease in acute myeloid leukemia patients using circulating leukemic cells selected from blood. Jackson JM, Taylor JB, Witek MA, Hunsucker SA, Waugh JP, Fedoriw Y, Shea TC, Soper SA, Armistead PM. Analyst. 2016 Jan 21;141(2):640-51. doi: 10.1039/c5an01836f. PMID: 26523411; PMCID: PMC4701594
  14. Cancer: a global concern that demands new detection technologies. Soper SA, Rasooly A. Analyst. 2016 Jan 21;141(2):367-70. doi: 10.1039/c5an90101d. PMID: 26688866; PMCID: PMC4777894
  15. Improved clinical sensitivity detection of circulating tumor cell assays using a dual selection strategy in women with epithelial ovarian cancer W.Z. Wysham, M.A. Witek, S.A. Soper, P.A. Gehrig, J.E. Stine.
  16. Current and future bioanalytical approaches for stroke assessment. Pullagurla SR, Baird AE, Adamski MG, Soper SA. Bioanalysis. 2015;7(8):1017-35. doi: 10.4155/bio.15.40. PMID: 25966012
  17. Enzymatic cleavage of uracil-containing single-stranded DNA linkers for the efficient release of affinity-selected circulating tumor cells. Nair SV, Witek MA, Jackson JM, Lindell MA, Hunsucker SA, Sapp T, Perry CE, Hupert ML, Bae-Jump V, Gehrig PA, Wysham WZ, Armistead PM, Voorhees P, Soper SA. Chem Commun (Camb). 2015 Feb 21;51(15):3266-9. doi: 10.1039/c4cc09765c. PMID: 25616078; PMCID: PMC45520444
  18. Parallel affinity-based isolation of leukocyte subsets using microfluidics: application for stroke diagnosis. Pullagurla SR, Witek MA, Jackson JM, Lindell MA, Hupert ML, Nesterova IV, Baird AE, Soper SA. Anal Chem. 2014 Apr 15;86(8):4058-65. doi: 10.1021/ac5007766. Epub 2014 Apr 1. PMID: 24650222; PMCID: PMC4004188
  19. Circulating tumor cells as a biomarker of response to treatment in patient-derived xenograft mouse models of pancreatic adenocarcinoma. Torphy RJ, Tignanelli CJ, Kamande JW, Moffitt RA, Herrera Loeza SG, Soper SA, Yeh JJ. PLoS One. 2014 Feb 19;9(2):e89474. doi: 10.1371/journal.pone.0089474. PMID: 24586805; PMCID: PMC3929698
  20. Modular microsystem for the isolation, enumeration, and phenotyping of circulating tumor cells in patients with pancreatic cancer. Kamande JW, Hupert ML, Witek MA, Wang H, Torphy RJ, Dharmasiri U, Njoroge SK, Jackson JM, Aufforth RD, Snavely A, Yeh JJ, Soper SA. Anal Chem. 2013 Oct 1;85(19):9092-100. doi: 10.1021/ac401720k. Epub 2013 Sep 10. PMID: 23947293; PMCID: PMC3832346
  21. Circulating tumor cells as a possible marker for micrometastatic disease in patients with localized pancreatic cancer, R.D. Aufforth, J.J. Baker, M.A. Witek, J.W. Kamande, H.J. Kim, P. Kuan, S.A. Soper and J.J. Yeh, Annals of Surgical Oncology, 20 (2013) S129
  22. Arrays of High-Aspect Ratio Microchannels for High-Throughput Isolation of Circulating Tumor Cells (CTCs). Hupert ML, Jackson JM, Wang H, Witek MA, Kamande J, Milowsky MI, Whang YE, Soper SA. Microsyst Technol. 2014 Oct 1;20(10-11):1815-1825. doi: 10.1007/s00542-013-1941-6. PMID: 25349469; PMCID: PMC4207852
  23. High-throughput selection, enumeration, electrokinetic manipulation, and molecular profiling of low-abundance circulating tumor cells using a microfluidic system. Dharmasiri U, Njoroge SK, Witek MA, Adebiyi MG, Kamande JW, Hupert ML, Barany F, Soper SA. Anal Chem. 2011 Mar 15;83(6):2301-9. doi: 10.1021/ac103172y. Epub 2011 Feb 14. PMID: 21319808; PMCID: PMC4380022
  24. Microsystems for the capture of low-abundance cells. Dharmasiri U, Witek MA, Adams AA, Soper SA. Annu Rev Anal Chem (Palo Alto Calif). 2010;3:409-31. doi: 10.1146/annurev.anchem.111808.073610. PMID: 20636049
  25. Highly efficient capture and enumeration of low abundance prostate cancer cells using prostate-specific membrane antigen aptamers immobilized to a polymeric microfluidic device. Dharmasiri U, Balamurugan S, Adams AA, Okagbare PI, Obubuafo A, Soper SA. Electrophoresis. 2009 Sep;30(18):3289-300. doi: 10.1002/elps.200900141. PMID: 19722212; PMCID: PMC3010183
  26. Highly Efficient Circulating Tumor Cell Isolation from Whole Blood and Label-Free Enumeration Using Polymer-Based Microfluidics with an Integrated Conductivity Sensor, A.A. Adams, P. Okagbare, J. Feng, R.L. McCarley, M.C. Murphy and S.A. Soper, J. Am. Chem. Soc. 130 (2008) 8633-8641